Oklahoma led 13-7 at halftime and shut Florida out in the second half, adding 10 points in the fourth quarter.
Oklahoma held the ball 37:50, converted 10 of 18 third downs to Florida's 2 of 9, and forced 2 interceptions without a turnover.
John Mateer threw for 207 yards and 2 touchdowns and led Oklahoma with 56 rushing yards; Florida's Tramell Jones Jr. went 10 of 22 with 2 interceptions.