Jacksonville won 33-10 on the road at Baltimore's M&T Bank Stadium.
The Jaguars led 17-3 at half-time, and Baltimore had just 3 points through three quarters before scoring 7 in the fourth.
Turnovers decided it: Baltimore gave the ball away 3 times, including 2 interceptions, to Jacksonville's 1. Baltimore passed for 55 yards to Jacksonville's 242.
Baltimore outrushed Jacksonville 172 to 77, with Justice Hill gaining 85 yards and a touchdown on 9 carries, but it wasn't enough.
Trevor Lawrence went 16 of 26 for 242 yards and a touchdown. Jacksonville moves to 6-2 and Baltimore falls to 4-5.